Abstract
A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.
MeSH terms
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Animals
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Indoles / chemical synthesis*
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Indoles / pharmacology*
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Mice
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Models, Molecular
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Molecular Structure
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N-Methylaspartate / pharmacology*
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Indoles
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Receptors, N-Methyl-D-Aspartate
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N-Methylaspartate